产品货号：
Z13161
中文名称：
CHEK2抗体
英文名称：
Anti-CHEK2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CHEK2 Antibody |
| 指标别名 | CDS1;CHEK2;Chk2;HuCds1;LFS2;PP1425;RAD53 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CHEK2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Chk2 (465-498aa KLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDL),different from the related mouse sequence by four amino acids. |
| 实际分子量 | 62KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CHK2,a protein kinase that is activated in response to DNA damage,is involved in cell cycle arrest.Mapped on 22q12.1,CHK2 has a potential regulatory region rich in SQ and TQ amino acid pairs.It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA1.Additionally,CHK2 can be modified by phosphorylation and activated in response to ionizing radiation,and can be also modified in response to hydroxyurea treatment.Furthermore,oligomerization of CHEK2 increases the efficiency of transautophosphorylation,resulting in the release of active CHEK2 monomers that proceed to enforce checkpoint control in irradiated cells.Moreover,CHK2 is a tumor suppressor gene conferring predisposition to sarcoma,breast cancer,and brain tumors,and that their observations provided a link between the central role of p53 inactivation in human cancer and the well-defined G2 checkpoint in yeast.There is a wide expression of small amounts of CHK2 mRNA with larger amounts in human testis,spleen,colon,and peripheral blood leukocytes. |
| Uniprot ID | O96017 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | checkpoint kinase 2 |
| 蛋白名全称 | Serine/threonine-protein kinase Chk2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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